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Anovulation


Anovulation is a state in which ovulation is absent. Approximately, 35% of women experience anovulation. This is a result of hormonal imbalance or due to the improper development of the ovaries. This is when the formation of the ovum (egg) in the ovary is disturbed. The most known cause of this abnormality is the polycystic ovarian syndrome (PCOS). Polycystic Ovarian Syndrome (PCOS) is a hormonal disorder that causes irregular menstrual cycles or lack of menstruation (amenorrhea), obesity and features of hyperandrogenism like acne and hirsutism. The origin of this hormonal disorder may be in the hypothalamus, pituitary gland, or in the ovary itself.


The initiation of the treatment involves restoring weight and lifestyle changes. If normalization of menstrual cycle and ovulation is not achieved, the next step is medical treatment with medications or injectable hormones to normalize the hormonal functions and stimulate ovulation. Ovarian drilling (making small holes on the ovary's surface by using heat or laser) is also considered to improve the ovarian hormonal microenvironment.


Pathological factors


Endometriosis


Endometriosis is a state when the tissue that lines the uterus also grows outside uterus. Women who are afflicted with endometriosis show symptoms of increasingly painful menstruation (dysmenorrheal), menstruation that is abnormal in intensity (whether heavy or light), pain during sexual intercourse (dysparuenia) and infertility. Endometriosis can also cause blood cysts in the ovaries. Endometriosis might also be caused by the effect on the tubes' functionality, which is caused by the inflammatory and wound-healing component of the endometrial tissue. However, the presence of a family hereditary factor might also be responsible. Nearly 35% of infertile women suffer from endometriosis.
Surgical treatment by laparoscopy (diathermy/argon) is usually prescribed to improve the patient's fertility.
 
Tubal Factors
Between 20-25 percent of all cases of infertility are related to tubal factor. Tubal factor infertility includes cases of either blocked fallopian tubes or partially blocked fallopian tubes, one of the two tubes blocked, and other types of damage to the fallopian tubes.
The result of endometriosis, or PCOS, tubal factor infertility is a prominent factor in problems of infertility in women. Scar tissue formed by endometrial tissue, surgery, or cysts, also create long-term difficulties when it comes to conception. Sometimes the tubal damage is not very serious. Nevertheless, when after standard fertility testing is performed there is no other obvious cause of infertility found, it is generally attributed to tubal factor infertility. Where cases of minimal scarring are found, a diagnosis of unexplained infertility is given.


Primary Cause of Tubal Factor Infertility
The primary cause of tubal factor infertility is pelvic inflammatory disease which is generally caused by either gonorrhea or Chlamydia infection that has travelled from the cervix through the uterus and into the fallopian tubes. As the body releases white blood cells to combat the infection, the tubes fill with pus and the bacteria are either brought under control or they are destroyed. Sadly, the darnage that is associated with this battle is the destruction of the inner lining of the tubes, which become permanently scarred. The end of the tube or tubes may become blocked with scar tissue as can the ovaries. Damage may be minimized if the infection is caught early enough and treated aggressively with antibiotics.
Tubo-peritoneal factors
Nearly 25% of female infertility cases occur due to a tubal factor, i.e. a disorder of the Fallopian tubes. Fallopian tubes function as an integral part in the reproduction process. The Fallopian tubes pick up the ovum released during ovulation, transport the spermatozoa towards the ovum and carry the fertilized ovum to the uterus. Damage to the Fallopian tubes will interfere in these vital functions and hence, prevent pregnancy. The tubo-peritoneal factor can cause an ectopic pregnancy (pregnancy in the Fallopian tube). Tubal damage can occur due to:

  • Genital tuberculosis
  • Infections arising from the uterine cervix or (Pelvic Inflammatory Disease, PID). The bacterial infections involved with PID are Gonorrhea and Chlamydia which produce an inflammatory reaction causing scarring and fibrosis that prevents the proper functioning of the Fallopian tubes.
  • A previous pelvic surgery can produce adhesions around the tubes or endometriosis which might cause tubal blockage
  • Infections arising from the abdominal cavity, e.g. Appendicitis
  • The Fallopian tube gets filled with inflammatory fluids and thus, becomes a potential source of chronic infections which results in Hydrosalpinx.
  • Tubal damage can be treated by endoscopic surgery, tubal microsurgery and ART techniques like IVF/ICSI.

Uterine Factors
In general cases, the embryo implants in the uterine cavity, so if the cavity has anatomical factors like fibroids, polyps or adhesions inside it, the embryo will fail to implant. In addition, some women may be having congenital anomalies of the uterine cavity like an intrauterine septum or bicornuate uterus . The miscarriage rate among women with a large uterine septum is quite high.
Fortunately the majority of the above conditions can be corrected or resected surgically and is usually followed by a subsequently normal implantation rate.

Latest News

  • CME - Haryana
    Topic- "Recent Development in ART (Artificial Reproductive Technologies)"

    2018-02-02 read more...

  • Ahemadabad Yuva-ISAR 2017
    Dr Nishant Dixit delivered a lecture on Oral Ovulogens and Adjuvants

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  • CME Jaipur
    Dr. Nishant Dixit gave talk on the topic individualised IVF Protocol. Dr. Nishant Dixit is the director of Nishant Fertility Centre (NFC), a highly experienced reproductive medicine specialist, Dr. Dixit has devoted his profession life to helping couples achieve their dream becoming parents .

    2017-04-20 read more...

  • CME Kota
    Dr. Nishant Dixit gave talk on the topic current trends in the medical managements of male infertility. Dr. Nishant Dixit is the director of Nishant Fertility Centre (NFC), a highly experienced reproductive medicine specialist, Dr. Dixit has devoted his profession life to helping couples achieve their dream becoming parents .

    2017-04-02 read more...

  • CME Kotputali
    Dr. Nishant Dixit gave talk on the topic current trends in the Neoadjuvant therapy for PCOS. Dr. Nishant Dixit is the director of Nishant Fertility Centre (NFC), a highly experienced reproductive medicine specialist, Dr. Dixit has devoted his profession life to helping couples achieve their dream becoming parents .

    2017-04-01 read more...

  • Gangapur City CME
    Dr. Nishant Dixit gave talk on the topic recent advances in the management of PCOS. Dr. Nishant Dixit is the director of Nishant Fertility Centre (NFC), a highly experienced reproductive medicine specialist, Dr. Dixit has devoted his profession life to helping couples achieve their dream becoming parents.

    2016-08-18 read more...

  • CME Alwar
    Dr. Nishant Dixit gave talk on the topic what gynecologist needs to know about male inferlity. Dr. Nishant Dixit is the director of Nishant Fertility Centre (NFC), a highly experienced reproductive medicine specialist, Dr. Dixit has devoted his profession life to helping couples achieve their dream becoming parents .

    2016-05-16 read more...

  • Conference at Jaipur ACE - 2016
    Dr. Nishant Dixit gave talk on the topic optimization of IVF results and became chair person in few sessions.. Dr. Nishant Dixit is the director of Nishant Fertility Centre (NFC), a highly experienced reproductive medicine specialist, Dr. Dixit has devoted his profession life to helping couples achieve their dream becoming parents.

    2016-05-16 read more...

  • Sikar CME
    Dr. Nishant Dixit gave talk on the topic management of Endometriosis in Infertility. Dr. Nishant Dixit is the director of Nishant Fertility Centre (NFC), a highly experienced reproductive medicine specialist, Dr. Dixit has devoted his profession life to helping couples achieve their dream becoming parents.

    2016-04-13 read more...

  • Conference at Helsinki (Finland), ESHRE - 2016
    Dr. Nishant Dixit actively participated in the world confrence of Europian Society of Human Reproduction and Embryology. Dr. Nishant Dixit is the director of Nishant Fertility Centre (NFC), a highly experienced reproductive medicine specialist, Dr. Dixit has devoted his profession life to helping couples achieve their dream becoming parents.

    2016-04-13 read more...

  • Ajmer CME
    Dr. Nishant Dixit gave talk on the topic Ovulation Induction Protocol for IVF. Dr. Nishant Dixit is the director of Nishant Fertility Centre (NFC), a highly experienced reproductive medicine specialist, Dr. Dixit has devoted his profession life to helping couples achieve their dream becoming parents.

    2016-02-13 read more...

  • Conference at Lisbon (Portugal), ESHRE - 2015
    Dr. Nishant Dixit actively participated in the world confrence of Europian Society of Human Reproduction and Embryology. Dr. Nishant Dixit is the director of Nishant Fertility Centre (NFC), a highly experienced reproductive medicine specialist, Dr. Dixit has devoted his profession life to helping couples achieve their dream becoming parents.

    2015-02-13 read more...

Patient Success Stories

Sapna & Deepak Ojha

Sapna & Deepak Ojha

Usha & Avinash

Usha & Avinash

Hemlata & Hament

Hemlata & Hament

Manbhar & Jagdeesh

Manbhar & Jagdeesh

Mamta & Niranjan

Mamta & Niranjan

Kamlesh & Mukesh

Kamlesh & Mukesh

Hem Kawar & Janak Singh

Hem Kawar & Janak Singh

Radha Singh FA - Faridabad

Radha Singh FA - Faridabad

Testimonials

“Thank you, Dr. Nishant Dixit, for your kindness and attention throughout my treatment. I appreciated your gentle manner and recommendations. Your patients are lucky to have you! ”


Sapna & Deepak Ojha

"Dr. Nishant Dixit & Care Team, we cannot thank you enough for making our dreams come true. Our little babies are a miracle and wouldn’t have been possible without your knowledge and care. Thank you again."


Mamta & Niranjan

"Dr. Nishant Dixit and her care team are simply the best! They are knowledgeable but also completely down to earth, approachable, and encouraging. I am lucky to have her as my doctor!"


Usha & Avinash

"Thank you Dr. Nishant Dixit for your positive, understanding, encouragement and compassion. Keep up the awesome work. I highly recommend you to those that need these services."


Hemlata & Hament

"Thank you so much for giving me hope and making my dreams come true. I am so glad I got referred to you and that you didn’t give up on me. Thanks for making this the best Day ever."


Manbhar & Jagdeesh

"Thank you! does not express our gratitude to you for helping bring our little sweet baby home to us, finally! You are all simply amazing and will be so forever!!!”


Kamlesh & Mukesh

"Hi Nishant Dixit, My partner and I are complete! A little baby entered our world. The process was worth it! Thank you for your dedication to our case."


Radha Singh FA - Faridabad

"I am really glad to say that I am under the treatment in Nishant Fertility Centre. After a long time my waiting has come true. Its an unforgettable moment in my life. Thanks to Dr. Nishant Dixit."


Hem Kawar & Janak Singh